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Patients at high risk of hydrocodone bitartrate and acetaminophen tablets abuse include those with a history of prolonged use of any opioid, including products containing hydrocodone, those with a history of drug or alcohol abuse, or those who use hydrocodone bitartrate and acetaminophen tablets in combination with other abused drugs

Treated mice show preservation of striatal dopamine levels and TH-positive neuron counts in the substantia nigra compared to untreated toxin-lesioned controls (45)

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